The No. 2 seed was 3-1 down in the third before breaking back and beating Khachanov 4-6, 6-3, 7-5. Tsitsipas is seeking his first tour title since February 2020.
Chardy saved two match points at 6-5 down in the second set. In the decider, Rublev sealed the win with his 15th ace on his fourth match point. Rublev is aiming to reach his first final of 2021 after going 5-0 in tour finals last year.